tina huang data scientist

October 28 Actress #31. Lcuyer, C., Hillaire-Marcel, C., Burke, A., Julien, M. A. Extended Data Fig. In particular, the model achieves 96.21% for the validation and 96.47% for testing using the news aggregator data. Think about some of your favorite apps today: Instagram, Uber, Facebook, and YouTube. K.N., V.V.-M., R.R., T. Ferraz, R.T., D.G.D., M.L., A. Modi, S. Vai, T. Saupe, C.L.S., G. Catalano, L. Pagani, D.C. and E.A. Rep. 10, 21931 (2020). 19-78-10053). Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. 3). Nat. 7 and Supplementary Table 3), which coincides roughly with the first appearance of the Oberkassel ancestry in central Europe. What is surprising is that the Code Cup was so popular that Stanford decided to throw open a Data Science Week in which anyone can submit a code challenge to the top 200 submissions. Dismiss. The tool qpAdm 810 in ADMIXTOOLS 5.1 was applied to model the ancestries of admixed populations, with allsnps mode and the outgroup set selection described in Supplementary Information, section11. 25, 459466 (2015). Moreover, none of the Epigravettian-associated individuals have more affinity to southern European than to central-eastern European Gravettian-associated groups, as shown by f4(Mbuti, Epigravettian-associated individual/group; Vstonice, Paglicci 12) that is consistent with 0 (Supplementary Data 2.G). Required fields are marked *. Ecol. To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. We also do experiments to test out the features we build and see how users respond to them. We can have either structured data (e.g. Look here to get updated on my recent favourite books, animes, filming equipment and more! The human remains were processed in dedicated laboratories at the Max Planck Institute for the Science of Human History in Jena (Germany), University of Tbingen (Germany), University of Florence (Italy), Leiden University Medical Center (the Netherlands) and University of Tartu (Estonia). The libraries underwent shallow shotgun sequencing on an Illumina HiSeq 4000 instrument with 75 single-end-run cycles using the manufacturers protocol, to evaluate the human endogenous DNA content and quality. Consultant - October 2015 to June 2016. Youll be surprised how much value there is in a quick XGBoost model, for example. After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. Dotted lines delimit geographic regions described in the text. What is Marimekko Chart in Data Visualization? The deduplicated bam files were filtered using PMDtools 0.6068 with a threshold of 3, to reduce potential modern DNA contamination based on postmortem DNA deamination. Tinas authentic and engaging delivery style allows her to create original content on topics like how to be more productive, how to learn more efficiently, how to land a job in data science, and more. Populations headed south? c, MDS plot of European hunter-gatherers based on 1f3(Mbuti; pop1, pop2). Considering a freshwater reservoir signal in the upper Volga region making radiocarbon dates on human remains appear up to about 500 years older than their true age44, there could be an interval of more than 1,000 years between the first evidence of admixture in central European hunter-gatherers with Sidelkino ancestry and eastern European hunter-gatherers with Oberkassel ancestry. Libraries were quantified using the IS7 and IS8 primers59 in a quantification assay using a DyNAmo SYBR Green qPCR Kit (Thermo Fisher Scientific) on the LightCycler 480 (Roche). Paradis, E., Claude, J. What is a Scatterplot in Data Visualization, Machine Learning in R: Building a Classification Model. Skoglund, P. et al. 132, Tables 14 and references. 6, 8912 (2015). Mid and Late Upper Palaeolithic in the Adriatic Basin: chronology, transitions and human adaptations to a changing landscape. . Planning and Learning in Partially Observable Systems via Filter Stability Noah Golowich (MIT); Ankur Moitra (Math & CSAIL, MIT); Dhruv Rohatgi (MIT) New Subset Selection Algorithms for Low Rank Approximation: Offline and Online David P. Woodruff, Taisuke Yasuda (Carnegie Mellon University) Good Quantum LDPC Codes with Linear Time Decoders Irit Dinur (Weizmann); Min-Hsiu Hsieh (Hon Hai Quantum . Cosimo Posth, He Yu, Ayshin Ghalichi, Hlne Rougier, Isabelle Crevecoeur, Yilei Huang, Harald Ringbauer, Adam B. Rohrlach, Kathrin Ngele, Vanessa Villalba-Mouco, Rita Radzeviciute, Tiago Ferraz, Alexander Stoessel, Rezeda Tukhbatova, Dorothe G. Drucker, Martina Lari, Alessandra Modi, Stefania Vai, Tina Saupe, Christiana L. Scheib, Giulio Catalano, Luca Pagani, Sahra Talamo, Helen Fewlass, Laurent Klaric, Andr Morala, Mathieu Ru, Stphane Madelaine, Laurent Crpin, Jean-Baptiste Caverne, Emmy Bocaege, Stefano Ricci, Francesco Boschin, Priscilla Bayle, Bruno Maureille, Foni Le Brun-Ricalens, Jean-Guillaume Bordes, Gregorio Oxilia, Eugenio Bortolini, Olivier Bignon-Lau, Grgory Debout, Michel Orliac, Antoine Zazzo, Vitale Sparacello, Elisabetta Starnini, Luca Sineo, Johannes van der Plicht, Laure Pecqueur, Gildas Merceron, Graldine Garcia, Jean-Michel Leuvrey, Coralie Bay Garcia, Asier Gmez-Olivencia, Marta Potowicz-Bobak, Dariusz Bobak, Mona Le Luyer, Paul Storm, Claudia Hoffmann, Jacek Kabaciski, Tatiana Filimonova, Svetlana Shnaider, Natalia Berezina, Borja Gonzlez-Rabanal, Manuel R. Gonzlez Morales, Ana B. Marn-Arroyo, Beln Lpez, Carmen Alonso-Llamazares, Annamaria Ronchitelli, Caroline Polet, Ivan Jadin, Nicolas Cauwe, Joaquim Soler, Neus Coromina, Isaac Ruf, Richard Cottiaux, Geoffrey Clark, Lawrence G. Straus, Marie-Anne Julien, Silvia Renhart, Dorothea Talaa, Stefano Benazzi, Matteo Romandini, Luc Amkreutz, Herv Bocherens, Christoph Wiing, Sbastien Villotte, Javier Fernndez-Lpez de Pablo, Magdalena Gmez-Puche, Marco Aurelio Esquembre-Bebia, Pierre Bodu, Liesbeth Smits, Bndicte Souffi, Rimantas Jankauskas, Justina Kozakait, Christophe Cupillard, Hartmut Benthien, Kurt Wehrberger, Ralf W. Schmitz, Susanne C. Feine, Tim Schler, Corinne Thevenet, Dan Grigorescu, Friedrich Lth, Andreas Kotula, Henny Piezonka, Franz Schopper, Ji Svoboda, Sandra Szelov, Andrey Chizhevsky, Aleksandr Khokhlov, Nicholas J. Conard, Frdrique Valentin, Katerina Harvati, Patrick Semal, Bettina Jungklaus, Alexander Suvorov, Rick Schulting, Vyacheslav Moiseyev, Kristiina Mannermaa, Alexandra Buzhilova, Thomas Terberger, David Caramelli, Eveline Altena, Wolfgang Haak, Johannes Krause. Are you Tina Huang? Petr, M., Pbo, S., Kelso, J. A dynastic elite in monumental Neolithic society. The aligned sequences of all individuals with new genomic data reported in this study are available at the European Nucleotide Archive (ENA) under study accession number PRJEB51862. Radiocarbon 51, 337360 (2009). The MySQL engine is also known for being extremely slow compared to others. Within Sicily, the 14ka Oriente C individual shows higher affinity with the much younger but geographically closer 10ka Uzzo group30 (n=2) than with the almost contemporaneous San Teodoro 2 individual from eastern Sicily. Lipson, M. et al. In many cases, this means loading data into a relational database (such as MySQL, MS SQL Server, or Oracle). The observation that post-14ka individuals from western and central Europe andalso from Britain41 carry a homogeneous genetic makeup instead of displaying repeated local admixtures with GoyetQ2 ancestry implies that the Oberkassel-ancestry profile was already largely formed before its dispersal. These models are easy to implement as well as really helpful in deciding what to build and how much to invest in it. Remember, its the problem that defines the tools we use! Wyprodukowany w konwencji anime serial stanowi spin-off produkcji "Midzy nami, Misiami", ktrej reyserem wykonawczym . The genetic history of Ice Age Europe. Madrid, Madrid, Spain. Admixture graphs were reconstructed using qpGraph 6450, with allsnps mode to correct for low-coverage sample and Mbuti.DG set as the outgroup. The research team describes a large-scale genetic replacement that may have been caused, in part, by climatic changes that forced people to migrate: "At that time, the climate warmed up quickly and considerably and forests spread across the European continent. Article Charlton, S. et al. 2014-2020.4.01.16-0030) and C.L.S. Compared with the genetic diversity observed among all analysed Gravettian-associated groups, Epigravettian-associated individuals show significantly lower amounts of genetic diversity (two-tailed t-test, P<0.001) (Fig. Ecologizr. Further palaeogenomic studies on Upper Palaeolithic individuals from the Balkans will be essential for understanding whether southeastern Europe represents the source of the Villabruna ancestry and a climatic refugium for human populations during the LGM. Article Product development is, by far, my favorite data science use case for two main reasons. 16, 224 (2015). 2. b, Calibrated radiocarbon dates of individuals plotted in a. PubMedGoogle Scholar. Great explanations and feels like real interviews that helps me warm up myself before the real interview! As the coverage for most ancient samples was not sufficient for diploid genotype calling, we counted the reads covering selected phenotypic SNPs on reference or alternative alleles and computed the group-based allele frequencies following a maximum likelihood approach described in Mathieson et al.37. PLoS ONE 14, e0217996 (2019). The competition is based on a pretty strict data set thats been collected by the Stanford Computer Science department. Genetics and material culture support repeated expansions into Paleolithic Eurasia from a population hub out of Africa. Libraries showing a mitochondrial or nuclear contamination rate over 10% were considered substantially contaminated whereas those between 5 and 10% were considered marginally contaminated and were treated differently (details are provided in Supplementary Information, section3). USA 117, 1279112798 (2020). Hunter-gatherers carrying an admixed WHG/EHG genetic profile have been sequenced from various regions of northern and eastern Europe, raising the question of how these two types of ancestries formed and interacted with each other through time and space37,38,39,40. However, the research team found no evidence for this, on the contrary: hunter-gatherer populations associated with the Gravettian culture and living in central and southern Europe are no longer genetically detectable after the LGM. The ancestry found in individuals associated with the preceding Aurignacian culture from central Europe (GoyetQ116-1ancestry) gave rise to Gravettian-associated individuals from western and southwestern Europe. Bioinformatics 25, 17541760 (2009). All remains were sampled with the approval of the institutions responsible for the analysis of archaeological material. 2932 and Supplementary Table 4). My name is Tina Huang and Im a data scientist at a FAANG company. Fourth, we extend the finding of a large-scale genetic turnover as early as 14ka in central and western European hunter-gatherers associated with multiple techno-complexesFedermesser, Azilian and other Final Palaeolithic groups4despite considerable technological continuity with the preceding late Magdalenian. Previous studies have shown that two main hunter-gatherer ancestries were predominant across most parts of Europe after around 14kathat is, the western hunter-gatherer (WHG) ancestry, related to the Villabruna cluster, and the eastern hunter-gatherer (EHG) ancestry, showing affinity to both the Villabruna and the ancient north Eurasian (ANE) ancestry found in Upper Palaeolithic Siberian individuals4,36. Tina Huang Data Scientist. Genome-wide patterns of selection in 230 ancient Eurasians. Extended Data Fig. Brace, S. et al. The error bar shows the s.e.m. Biol. Rohrlach, A. Bronk Ramsey, C. Bayesian analysis of radiocarbon dates. Tina is a computer science student at Stanford University. Further information on research design is available in theNature Portfolio Reporting Summary linked to this article. Gansauge, M., Aximu-Petri, A., Nagel, S. & Meyer, M. Manual and automated preparation of single-stranded DNA libraries for the sequencing of DNA from ancient biological remains and other sources of highly degraded DNA. Details of the grouping and ROH segments are provided in Data S3.B. 412, 3743 (2016). Notably, and contrary to the report by Fu et al.4, another Gravettian-associated population from centralwestern Europe (Goyet in Belgium, n=6 individuals) is both geographically and genetically intermediate between the Vstonice and Fournol clusters. Evol. Negative and positive controls were carried alongside each experiment. Genet. We detect the highest amount of ROHs in Epigravettian-associated individuals from Sicily, who carry an extreme amount of more than 200cM of short ROHs (48cM). In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a . The Kostenki (and Sunghir group) ancestry contributed to the previously described Vstonice cluster represented by Gravettian-associated individuals from central-eastern and southern Europe4. The compiled genotype file used for analyses, including re-genotyped published genomes, has been uploaded at the Edmond Data Repository of the Max Planck Society (https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF). Brunel, S. et al. Tina Huang: Data science, computer science, and career advice expert. The pre-40kagroup and theFournol and Vstonice clusters are marked as shaded areas in different colours. My name is Tina and I'm a data scientist and YouTuber. In the MDS plot, the Le Piage II individual falls particularly close to individuals belonging to the Fournol cluster, suggesting a local genetic continuity of this ancestry during the LGM (Supplementary Fig. Tina K. Sorensen. Fu, Q. et al. 9). Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry, A genomic Neolithic time transect of hunter-farmer admixture in central Poland, Palaeo-Eskimo genetic ancestry and the peopling of Chukotka and North America, A genetic history of the pre-contact Caribbean, Ancient genomes from the last three millennia support multiple human dispersals into Wallacea, Ancient DNA reveals admixture history and endogamy in the prehistoric Aegean, A 23,000-year-old southern Iberian individual links human groups that lived in Western Europe before and after the Last Glacial Maximum, Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia, Ancient DNA from mastics solidifies connection between material culture and genetics of mesolithic huntergatherers in Scandinavia, https://github.com/stschiff/sequenceTools, https://reich.hms.harvard.edu/allen-ancient-dna-resource-aadr-downloadable-genotypes-present-day-and-ancient-dna-data, https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF, https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html, https://doi.org/10.1007/978-94-017-7206-8_6, https://doi.org/10.1038/s41559-023-01987-0.

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